Tottenhamgreen House was built around 1700 on a gentle south-facing slope in County Wexford, most likely on the same ground where an earlier castle called Ballinloskran had stood. That older structure is thought to be the same Ballinloskran recorded in the Civil Survey of 1654 to 1656, which placed it between the Corrock River, Shanowle, and Horetown. The house that replaced it was a composed, formal piece of early eighteenth-century architecture: five bays wide, one storey over a high basement and attic, with a large pediment dominating the entrance front. Around 1712 a wing was added to one end, built in the same style, giving the whole composition a careful symmetry. It was demolished around 1950.

The land's earlier history points to the disruptions that reshaped property ownership in seventeenth-century Ireland. A grant of 478 acres in Ballyloskan was made in 1667 to a Charles Collins, part of the wave of redistributions that followed the Cromwellian settlement. Collins subsequently sold the land to John Tottenham of Ballyduff in County Waterford, and it was Tottenham's name that eventually attached itself to the townland. The family's mark on the landscape proved more durable than the house itself, which survived nearly two and a half centuries before being taken down within living memory of the present era.