The manse house of the Prebendary of Tascoffin, a canon attached to the chapter of St Canice's Cathedral, once occupied the ground between what is now Nos 21 and 22 Vicar Street. A prebendary was a cathedral clergyman whose income derived from a specific landholding or endowment, in this case associated with Tascoffin, and his manse, or official residence, sat in a tight cluster of ecclesiastical properties alongside the chancellor's manse to the northwest and the vicar's house to the southeast. Number 22 was demolished in 2014 as part of the Kilkenny Central Access Scheme, removing any chance of reading the later fabric of the site above ground.

The clearest picture of what once stood here comes from historical sources rather than surviving stone. Writing in 1781, Edward Ledwich recorded that the manse was bounded to the east and north by the chancellor's orchard, to the west by King Street, and to the south by the vicar's house, a description that conveys a generous, almost self-contained precinct. John Hogan, writing in 1884, judged it to have been "formerly very extensive" and read John Rocque's 1758 map of Kilkenny as showing the building's footprint stretching eastward almost halfway to the River Nore. That same map depicts a long east-west structure running between the vicar's house gable and Mill Lane. Archaeological monitoring carried out in 1998 by Patrick Neary on the north side of No. 22 recorded a battered wall, that is, a wall with an angled or sloping base, which is likely a surviving fragment of the manse itself. The north gable of the adjoining vicar's house remains standing, a sole piece of medieval fabric in an otherwise much-altered streetscape, offering a faint material echo of the ecclesiastical neighbourhood that once lined this quiet Kilkenny lane.